Careers

Exicure is developing a new class of immunomodulatory and gene silencing drugs against validated targets, addressing diseases from inflammatory disorders to oncology. We strive to unlock the potential of nucleic acid therapeutics with our 3-dimensional, spherical nucleic acid (SNA™) constructs. SNA constructs have the potential to overcome one of the most difficult obstacles to nucleic acid therapeutics: safe and effective delivery into cells and tissues.

We seek employees who have the passion to help us drive this innovative technology forward to the patients in need and thrive in a fast-paced atmosphere. We are always interested in receiving resumes from highly skilled and experienced candidates. Please send your resume and cover letter to: careers at exicuretx dot com.

Currently, we are hiring for the following positions:

Oligonucleotide Chemistry Scientist

Candidates applying for oligonucleotide chemistry Scientist position should have a PhD in Organic/Medicinal Chemistry or a related subject area with no more than a year of industrial/postdoctoral experience. Preference will be given to candidates with hands on experience in chemical synthesis, purification and characterization of DNA/RNA. Hands on experience in one or more areas of the following is essential: running small to large scale automated DNA/RNA synthesizers, solid phase synthesis of oligonucleotides at various scales, chemical modifications of nucleosides and backbones, purification of oligonucleotides at different scales by anion-exchange and reverse-phase HPLC systems, analysis of oligonucleotides by various established methods, including UV spectrophotometry, anion exchange HPLC, reverse phase HPLC, size-exclusion chromatography, gel electrophoresis and ESI and/or MALDI/ToF mass spectrometry. Experience in biophysical and biochemical characterization of oligonucleotides is desirable but not necessary. Working knowledge and understanding of nanoparticle or liposomal formulation of oligonucleotides and/or molecular biological and immunological techniques is an added advantage to work along with the team members. Candidates should have attention to detail, excellent organizational and reasoning skills along with independent experimental design and data analysis skills. Independence, resourcefulness, and ability to work cooperatively in a high performing multidisciplinary team environment are a must. Excellent written and verbal communication skills are required.

Formulation Scientist

Candidates applying for formulation Scientist position should have a PhD in nano/biotechnology or any related subject area with no more than a year of industrial/postdoctoral experience. Preference will be given to candidates with hands on experience with lipid formulations, liposomes, extrusion or homogenization based liposome synthesis, tangential flow filtration (TFF), and nanoparticle characterization using dynamic light scattering (DLS), anion exchange HPLC, size-exclusion chromatography, cryoTEM, and gel electrophoresis. Experience in biophysical and biochemical characterization of oligonucleotide nanoparticles is desirable. Working knowledge and understanding of oligonucleotide chemistry and synthesis and/or molecular biological and immunological techniques is an added advantage to work along with the team members. Candidates should have attention to detail, excellent organizational and reasoning skills along with independent experimental design and data analysis skills. Independence, resourcefulness, and ability to work cooperatively in a high performing multidisciplinary team environment are a must. Excellent written and verbal communication skills are required.